I run LFS on my MacBook and sometimes in an iMac (when i'm too lazy to go to my room to get my MacBook:shy

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CrossOver Games for Mac runs LFS pretty good, although it somehow doesn't support any gameing hardware (wheel, gamepad etc.). So you'll have to do with keyboard and mouse.
Some games are 'officially supported', so those run best, but LFS does pretty well too (depending ofcourse on your mac's config.).
There's a company that uses cider to port software from pc to mac, big company's like EA already used it for 'Spore'. As Cider doesn't require to completely re-write the source code, I hope this will someday be used to make a OSX version of LFS as it's just a conversion, and not a complete rewrite.
I hope any of this awnsers the OP's question.