From the first day i got my G27 it would disconnect randomly than i went to Logitech and they gave me another one it still had the same problem Some times it would stay 2 to 3 Hours not disconnecting but sometimes every 15 Minutes or So I tried Everything But There Is nothing that worked. I Tried To change the power setting of the usbs Did Nothing. And For People Who Are Asking about What happens when the wheel "disconnects"? it dies completely and recalibrate itself then i can play unteil it does it again.

I would say try wheel on different PC

Secure the usb cable as tightly as you can!

Also you can try an usb cable extender