Other than the fact that I can't remove subscription videos from the front page (it's quite damn messy now..), I quite like it. The previous design was starting to be outdated for modern high resolution monitors.
I still prefer Cosmic Panda.
It has option of 720p player while in non-fullscreen, which is awesome. After using it for weeks, I can't go back to old (or this new one) layout with small 800*480 (or something) player.
Hm, at least on this laptop I seem to have this new design. I must say, this is not where I want youtube to go to. It's just really unpractical if you're subscribed to that many channels, I liked the stacking of the videos per channel.
It's not like I ever go to the youtube homepage, though... the only pages I really browse are the videos page (watching a video) and the search page. I wouldn't have noticed the homepage has changed if nobody said anything about it...